Abstract
The synthesis and evaluation of several chemical modulators of heat shock protein 90 (Hsp90) dimerization is presented. These agents may represent useful tools to study the importance of N-terminal dimerization and also to determine subunit interface(s) in Hsp90.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzoquinones
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Binding, Competitive / drug effects
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Dimerization
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HSP90 Heat-Shock Proteins / chemistry*
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HSP90 Heat-Shock Proteins / drug effects*
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Lactams, Macrocyclic
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Molecular Structure
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Quinones / chemical synthesis*
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Quinones / chemistry
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Quinones / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Benzoquinones
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HSP90 Heat-Shock Proteins
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Lactams, Macrocyclic
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Quinones
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geldanamycin